Pitfalls in Estimating Piperaquine Elimination
Open Access
- 1 December 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (12), 5127-5128
- https://doi.org/10.1128/aac.49.12.5127-5128.2005
Abstract
By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.Keywords
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