Activity of Ribosomes Containing 5S RNA with a Chemically Modified 3′-Terminus
Open Access
- 1 February 1972
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (2), 363-365
- https://doi.org/10.1073/pnas.69.2.363
Abstract
Ribosomes containing 5S RNA in which the 3′-terminus has been modified chemically, either by periodate oxidation or by conversion of the terminal ribose to a morpholine derivative, are fully as active in peptidebond formation and polypeptide synthesis as those ribosomes with unmodified 5S RNA. These results exclude models for protein synthesis in which peptidyl-5S RNA is formed as an intermediate.Keywords
This publication has 5 references indexed in Scilit:
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- Inactivation and reactivation of ribosomal subunits: The peptidyl transferase activity of the 50 s subunit of Escherichia coliJournal of Molecular Biology, 1970
- Nucleotide Sequence Analysis of Polyribonucleotides by Means of Periodate Oxidation Followed by Cleavage with an AmineJournal of Biological Chemistry, 1964
- The Reaction of Methylamine with Periodate-Oxidized Adenosine 5'-PhosphateBiochemistry, 1963