Hemoglobin Synthesis in Somatic Cell Hybrids: Independent Segregation of the Human Alpha- and Beta-Globin Genes
- 26 March 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4233), 1262-1264
- https://doi.org/10.1126/science.943846
Abstract
Hybrid somatic cells containing a partial complement of human chromosomes were used to demonstrate that the human alpha- and beta-globin genes are located on different chromosomes. Two cell lines consisting of a cross of mouse with human fibroblasts contained the human alpha- and not the beta-globin gene, while a cross of human marrow cells with mouse erythroleukemia cells expressed the human beta- but not the alpha-globin gene.This publication has 15 references indexed in Scilit:
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