Inhibition of allergic reactions due to competition for mast cell sensitization sites by two reagins.

  • 1 November 1971
    • journal article
    • Vol. 9 (5), 585-94
Abstract
The ability of unrelated or incidental reagin to interfere competitively with mast cell sensitization by specific reagin has been examined using an experimental system whereby rats are induced to produce high levels of reaginic (IgE) antibody to two antigens. It is shown that passive sensitization by a reaginic antibody is inhibited (a) by simultaneous injection with a second reagin directed against another antigen, the degree of inhibition being related directly to the dose of the second serum or (b) if the test animal is actively producing unrelated reagin.