A Polymer Coated Silica Gel for High-Performance Liquid Chromatography

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Abstract
The treatment of microparticulate silica gel with Carbowax 20M results in a stable and reproducible support which greatly reduces the irreversible adsorption effects observed for polyoxyethylene compounds on untreated silica gel. The selectivity of this coated support, likely a result of selective deactivation, permits the rapid separation of oligomers differing by ≤ 3% in molecular weight. The advantages and disadvantages of this support and a C18 reversed-phase support for the separation and analysis of polyoxyethylene oligomers and their adducts are illustrated and discussed.