Hyperuricemia in Diabetic Ketoacidosis

Abstract

THERE is considerable clinical^{1 2 3 4 5 6 7} and biochemical^{8 , 9} evidence suggesting but not firmly establishing a relation of uric acid with carbohydrate and lipid metabolism. Uric acid resembles alloxan in its chemical configuration, and there have been preliminary observations provoking the concept of "uric acid diabetes."^{8 , 9} Although the diabetogenic effects of uric acid have not been proved to exist in man there is at least some statistical evidence of a high incidence of diabetes with hyperuricemia or gout or both.^{3 , 7} Other observations include the influence of insulin on precipitating acute gout,¹⁰ the coincidence of hypercholesterolemia,³ hyperuricemia and hyperglycemia¹¹ and the effects of starvation, . . .