Cerebral Circulation of Man During Halothane Anesthesia

Abstract
Cerebral circulatory measurements were made in 13 young normal male volunteers anesthetized with 1.2% halothane in oxygen. Studies were performed at normal and at low PaCO2 with intravenous d-tubocurarine and at low PaCO2 without d-tubocurarine. During halothane anesthesia the cerebral vasculature was shown to constrict when PaCO2 was lowered, a response similar to that which has been observed in awake man. Halothane in the concentration studied was demonstrated to be a mild cerebral vasodilator. d-Tubocurarine was shown not to affect either cerebral blood flow, cerebral vascular resistance, or cerebral oxygen consumption. The relation of cerebral blood flow to the more easily measured jugular venous P02 is demonstrated and discussed.

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