THE EFFECT OF 5-HYDROXYTRYPTAMINE AND OF AN AMINE OXIDASE INHIBITOR ON EXPERIMENTAL DECIDUOMATA IN MICE

Abstract

SUMMARY: Investigations were carried out to study the mechanism by which 5-hydroxytryptamine (5-HT) and monoamine oxidase inhibitors interfere with pregnancy, using the experimental decidual reaction in mice. The results suggest that both 5-HT and an amine oxidase inhibitor, HP. 1325 (2,2′-(p-phenylenedioxy)-di-(ethyl hydrazinium (1+) chloride)), interfere with the endocrine activity of the ovary, particularly the corpus luteum, since their toxic effects on deciduomata are reversed by progesterone. In addition, 5-HT also has a direct toxic effect on decidual tissue.