Chromosome-Wide Event Accompanies the Expression of Recessive Mutations in Tetraploid Cells
- 21 March 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 187 (4181), 1091-1093
- https://doi.org/10.1126/science.1167702
Abstract
Mutants resistant to 6-thioguanine were induced in pseudotetraploid hybrid Chinese hamster cells homozygous wild-type at the locus for hypoxanthine phophoribosyl transferase but heterozygous for the linked marker glucose-6-phosphate dehydrogenase. About half of these mutants had concomitantly lost the wild-type allele for glucose-6-phosphate dehydrogenase, as expected if mutation plus chromosome segregation had occurred.Keywords
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