Variations on a Theme: Cataloging Human DNA Sequence Variation
- 28 November 1997
- journal article
- policy forum
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 278 (5343), 1580-1581
- https://doi.org/10.1126/science.278.5343.1580
Abstract
New methods for the discovery and scoring of single-nucleotide polymorphisms (SNPs) offer the potential for considerably improved methods for genetic analysis of complex biological phenomena, particularly common diseases. In this Policy Forum, the authors call for a publicly supported effort to discover a large number of SNPs and to place the information in public databases. Participation in this public effort by the private sector would be particularly desirable.Keywords
This publication has 15 references indexed in Scilit:
- Snipping Away at Genome PatentingScience, 1997
- Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)Nature, 1996
- It's the genes! EST access to human genome contentBioEssays, 1996
- The New Genomics: Global Views of BiologyScience, 1996
- Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization.Genome Research, 1995
- A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's diseaseCell, 1994
- Mutation of a mutL Homolog in Hereditary Colon CancerScience, 1994
- Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancerNature, 1994
- Positional cloning: Let's not call it reverse anymoreNature Genetics, 1992
- Light-Directed, Spatially Addressable Parallel Chemical SynthesisScience, 1991