GENETIC CONTROL OF THE IMMUNE RESPONSE TO HEN'S EGG‐WHITE LYSOZYME IN MICE: I. ANTIBODY AND T‐LYMPHOCYTE PROLIFERATIVE RESPONSES TO THE NATIVE PROTEIN*

Abstract

We have initiated studies to determine whether the antibody and T-lymphocyte proliferative responses to lysozyme and its antigenic sites is genetically controlled in mice. Mice of the H-2^f, H-2^k and H-2^p were high responders, while haplotypes H-2^b, H-2^d, H-2^r and H-2^s were low responders. Studies with recombinants indicated that the immune response is controlled by two H-2I region loci, one being in the I-A subregion and the other may be in the I-C subregions.