Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium
- 26 May 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 201 (1), 9-14
- https://doi.org/10.1016/0014-5793(86)80561-0
Abstract
In the guinea pig myometrium prelabelled with myo-[2-3H]inositol, carbachol and oxytocin enhanced a concentration-dependent and rapid release of IP3 which preceded that of IP2 and IP1. The specific receptor-mediated phospholipase C activation degrading PIP2 to IP3 did not require the presence of extracellular Ca2+. The ionophore A23187 as well as K+ depolarization failed to increase inositol phosphate accumulation. It is proposed that IP3 could have a role in the contraction of uterine smooth muscle elicited by the activation of muscarinic as well as of oxytocin receptors.Keywords
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