Green and Black Teas Inhibit Atherosclerosis by Lipid, Antioxidant, and Fibrinolytic Mechanisms
- 4 May 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 52 (11), 3661-3665
- https://doi.org/10.1021/jf035255l
Abstract
Tea is the most widely consumed beverage in the world, second only to water. Most laypersons and scientists believe that green tea is healthier than black tea due to the low incidence of heart disease and cancer in the Orient. Here, we report the first dose-response comparison of a green and black tea on normal hamsters after long-term supplementation and on a hamster model of atherosclerosis. Both teas were equally effective in inhibiting atherosclerosis with the lower dose decreasing it 26-46% and the high dose decreasing it 48-63%. Atherosclerosis was inhibited by three mechanisms: hypolipemic, antioxidant, and antifibrinolytic. There was a significant correlation between atherosclerosis and the three mechanisms. In the normal animals, teas also caused some improvement in plasma low density lipoprotein (LDL), LDL/high density lipoprotein ratio, triglycerides, lipid peroxides, lower density lipoprotein lipid peroxides, and fibrinogen. Isolated lower density lipoprotein oxidizability was also reduced in all groups. Green and black teas were equally effective at human equivalent doses, thus confirming human intervention and epidemiology studies and providing mechanisms for teas' benefit.Keywords
This publication has 15 references indexed in Scilit:
- Cholesterol-Lowering Effect of a Theaflavin-Enriched Green Tea ExtractArchives of Internal Medicine, 2003
- Effect of EGCG on lipid absorption and plasma lipid levels in ratsThe Journal of Nutritional Biochemistry, 2003
- Green Tea Upregulates the Low-Density Lipoprotein Receptor through the Sterol-Regulated Element Binding Protein in HepG2 Liver CellsJournal of Agricultural and Food Chemistry, 2001
- Relation between Green Tea Consumption and the Severity of Coronary Atherosclerosis among Japanese Men and WomenAnnals of Epidemiology, 2000
- Total energy expenditure in the elderlyEuropean Journal of Clinical Nutrition, 2000
- Effect of green and black tea supplementation on lipids, lipid oxidation and fibrinogen in the hamster: mechanisms for the epidemiological benefits of tea drinkingFEBS Letters, 1998
- Effect of Black Tea Polyphenols on Plasma Lipids in Cholesterol-Fed Rats.Journal of Nutritional Science and Vitaminology, 1998
- Manufacturing and Chemistry of TeaPublished by American Chemical Society (ACS) ,1992
- Tea consumption. Relationship to cholesterol, blood pressure, and coronary and total mortalityPreventive Medicine, 1992
- Growth of the Pre-erythrocytic Tissue Stages of Plasmodium berghei in Isolated, Perfused Tree Rat LiverNature, 1967