Light Chains of Mouse Myeloma Proteins: Partial Amino Acid Sequence
- 21 October 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 154 (3747), 391-393
- https://doi.org/10.1126/science.154.3747.391
Abstract
Five kappa chains in the urinary proteins of the BALB/c mouse have the same carboxyl terminal amino acid sequence; this sequence resembles that of kappa light chains in human immunoglobulins. The five chains have amino acid sequence variations at the amino-terminal. The genetic basis for the amino-terminal variations is not understood but could be due either to a mechanism for differently translating a single genetic message or to the presence of more than one kappa-type structural cistron in the BALB/c genome.Keywords
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