The inhibition site of MPP+, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase
- 1 December 1987
- journal article
- research article
- Published by Elsevier in Archives of Biochemistry and Biophysics
- Vol. 259 (2), 645-649
- https://doi.org/10.1016/0003-9861(87)90531-5
Abstract
No abstract availableThis publication has 20 references indexed in Scilit:
- Biochemical Events in the Development of Parkinsonism Induced by 1‐Methyl‐4‐Phenyl‐1,2,3,6‐TetrahydropyridineJournal of Neurochemistry, 1987
- Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ionBiochemical and Biophysical Research Communications, 1987
- Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidasesBiochemical Journal, 1986
- Studies on the Neurotoxicity of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine: Inhibition of NAD‐Linked Substrate Oxidation by Its Metabolite, 1‐Methyl‐4‐PhenylpyridiniumJournal of Neurochemistry, 1986
- Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonismBiochemical and Biophysical Research Communications, 1986
- Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+Biochemical and Biophysical Research Communications, 1986
- Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicityNeuroscience Letters, 1985
- Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineLife Sciences, 1985
- Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidaseBiochemical and Biophysical Research Communications, 1984
- ENZYMATIC PROPERTIES OF THE INNER AND OUTER MEMBRANES OF RAT LIVER MITOCHONDRIAThe Journal of cell biology, 1968