EXPERIMENTAL INTRAOCULAR INFECTION WITH MUMPS VIRUS

Abstract
EPIDEMIC parotitis is a virus infection which may manifest itself in multiple involvement of glandular and nerve tissue. The ocular manifestations of the disease may be divided into three categories: (1) involvement of glandular tissue (dacryoadenitis); (2) involvement of nerve tissue (optic neuritis, nystagmus, paralysis of extraocular muscles, paralysis of accommodation), and (3) involvement of ocular tissues proper (conjunctivitis, keratitis, scleritis, anterior uveitis, choroiditis). Clinical descriptions have been summarized by Bonnet1 and Bolletieri.2 A recent review of the literature has been compiled by North3; a number of published cases of mumps keratitis are summarized by Danielson and Long,4 with more recent cases added by Lippmann,5 Nectoux,6 Roussel,7 Fields,8 and Michálek and Iserle.9 No histological studies of human eyes affected by mumps are available. Experimentally, mumps virus has been reported by Bolin and associates10 to give a corneal reaction in the