THE DEIODINATIQN OF THYROXINE TO TRIIODOTHYRONINE BY KIDNEY SLICES OF RATS WITH VARYING THYROID FUNCTION1
- 1 September 1955
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 57 (3), 338-344
- https://doi.org/10.1210/endo-57-3-338
Abstract
Previously reported deiodination of thyroxin to triiodothyronine in vitro by rat kidney slices is confirmed. The deiodinating system is heat labile, and is inhibited by thiouracil and triiodothyronine. The deiodination of thyroxin by kidney slices of rats with varying thyroid function was studied. Kidney slices of hyperthyroid rats showed greater deiodinating activity and hypothyroid rats less than normal. The presence of an adaptive thyroxin deiodinating enzyme system conditioned by the level of thyroxin in the tissue is postulated.Keywords
This publication has 14 references indexed in Scilit:
- COMPARATIVE DISTRIBUTION AND FATE OF I131-LABELED THYROXINE AND TRIIODOTHYRONINE1Endocrinology, 1954
- The biological action of substances related to thyroxine. 8. The effects of butyl 4-hydroxy-3:5-diiodobenzoate on the deiodination of diiodotyrosine and thyroxine in ratsBiochemical Journal, 1954
- THE PHYSIOLOGIC ACTIVITY OF Z-TRIIODOTHYRONINE*Journal of Clinical Endocrinology & Metabolism, 1953
- Comparison of in vitro Serum Protein Binding of Thyroxin and Triiodothyronine.Experimental Biology and Medicine, 1953
- Single Dimension Chromatographic Separation of Thyroxin and Triiodothyronine.Experimental Biology and Medicine, 1953
- 1-TRIIODOTHYRONINE VERSUS 1-THYROXINE A COMPARISON OF THEIR METABOLIC EFFECTS IN HUMAN MYXEDEMAThe American Journal of the Medical Sciences, 1953
- 3:5:3′-Triiodothyronine. 2. Physiological activityBiochemical Journal, 1953
- A COMPARISON OF THE METABOLIC ACTIVITIES OF 3,5,3'-L-TRIIODOTHYRONINE AND L-THYROXINE IN MYXEDEMA1953
- Metabolites of Thyroxine.Experimental Biology and Medicine, 1951
- The biological action of substances related to thyroxine. 1. The effect of n-alkyl 3:5-diiodo-4-hydroxybenzoates on oxygen consumption in miceBiochemical Journal, 1951