Human β-Adrenoceptors: Relation of Myocardial and Lymphocyte β-Adrenoceptor Density
- 28 March 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 231 (4745), 1584-1585
- https://doi.org/10.1126/science.3006250
Abstract
In human right atria obtained from 21 patients during open-heart surgery, beta-adrenoceptor density [assessed by iodine-125-labeled (-)-cyanopindolol binding] and responsiveness (positive inotropic responses to isoprenaline) were linearly related to the beta-adrenoceptor density in the corresponding circulating lymphocytes. This direct relation of human myocardial and lymphocyte beta-adrenoceptor alterations, therefore, makes it possible to monitor drug- or disease-induced beta-adrenoceptor changes in tissues not easily accessible in humans.This publication has 18 references indexed in Scilit:
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