THE CLEARANCE OF HEXAMETHENAMINE IN THE DOG

Abstract

Comparisons of the simultaneously determined hexamethenamine, creatinine, and xylose clearances were made in the normal and the phlorizinized dog. The hexamethenamine/creatinine clearance ratio in the normal dogs is independent of the plasma concn. of hexamethenamine over a range of concns. from 56 to 561 mgm. %, hence the hexamethenamine clearance itself is independent of the plasma concn. of this substance. The simultaneous clearances of hexamethenamine and xylose are practically identical, both being about 75% of the simultaneous creatinine clearance. Phlorizin depresses the clearances of all 3 substances, altering the xylose clearance least. The hexamethenamine/creatinine ratio is not changed appreciably by phlorizin, while the xylose/creatinine clearance rises towards 1.0.