Antioxidant enzymes in RBCs as a biological index of age related macular degeneration
- 1 April 1993
- journal article
- Published by Wiley in Acta Ophthalmologica
- Vol. 71 (2), 214-218
- https://doi.org/10.1111/j.1755-3768.1993.tb04993.x
Abstract
The present study was undertaken to assess the levels of antioxidant enzymes in red blood cells of subjects with age-related macular degeneration and age-matched controls. The results obtained show a significant decrease in activities of superoxide dismutase (p < 0.001) and glutathione peroxidase (p < 0.001) as compared to the controls. A good correlation (r = -0.99) was also observed between age and decreased activity of antioxidant enzymes in controls, and also correlated well with age-related macular degeneration. In conclusion, oxidative stress as assessed by antioxidant enzymes is more pronounced in subjects with age-related macular degeneration as compared to age-matched controls.Keywords
This publication has 7 references indexed in Scilit:
- Antioxidant Enzymes in the Aging Human Retinal Pigment EpitheliumArchives of Ophthalmology (1950), 1991
- Protein, Lipid and DNA Repair Systems in Oxidative Stress: The Free-Radical Theory of Aging RevisitedGerontology, 1991
- Pathophysiology of age-related macular degenerationSurvey of Ophthalmology, 1987
- The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygenBiochemical and Biophysical Research Communications, 1972
- Massive Subretinal Exudation Associated with Senile Macular DegenerationAmerican Journal of Ophthalmology, 1971
- Measurement of catalase activity in tissue extractsAnalytical Biochemistry, 1970