Dissolution rates of sulfamethoxazole utilizing sugar glass dispersions

Abstract

Solid glass dispersions of sulfamethoxazole have been prepared by fusion using different classes of sugars, A marked increase in the dissolution rate of sulfamethoxazole in the solid dispersions was observed compared with that of the drug alone. During the fusion process, interaction took place between sulfamethoxazole and those sugars with carbonyl groups. The bacteriological activity of sulfamethoxazole was not changed by the interaction compared with dispersions in which the interaction did not occur.