The Design of Polyvalent Therapeutics
- 8 September 2008
- journal article
- review article
- Published by Wiley in Chemistry – A European Journal
- Vol. 14 (26), 7738-7747
- https://doi.org/10.1002/chem.200800278
Abstract
This article reviews recent developments in the design of polyvalent ligands for in vivo applications. Topics discussed include the design of polyvalent inhibitors of toxins and viruses, the use of polyvalency for targeted drug delivery and imaging, and applications of polyvalency for enhancing or suppressing immune responses.Keywords
This publication has 84 references indexed in Scilit:
- Folic Acid-Mediated Targeting of Cowpea Mosaic Virus Particles to Tumor CellsChemistry & Biology, 2007
- Effects of Saccharide Spacing and Chain Extension on Toxin Inhibition by Glycopolypeptides of Well-Defined ArchitectureMacromolecules, 2007
- Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant toleranceProceedings of the National Academy of Sciences, 2007
- Biomimetic amplification of nanoparticle homing to tumorsProceedings of the National Academy of Sciences, 2007
- Polyvalent inhibitors of anthrax toxin that target host receptorsProceedings of the National Academy of Sciences, 2006
- Synthesis of Potent Inhibitors of Anthrax Toxin Based on Poly-l-Glutamic AcidBioconjugate Chemistry, 2006
- Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivoProceedings of the National Academy of Sciences, 2006
- Engineering novel binding proteins from nonimmunoglobulin domainsNature Biotechnology, 2005
- Carbohydrate vaccines as immunotherapy for cancerImmunology & Cell Biology, 2005
- Synthesis of a Divalent Sialyl Lewis x O‐glycan, a Potent Inhibitor of Lymphocyte‐Endothelium AdhesionEuropean Journal of Biochemistry, 1995