Giant Hepatic Mitochondria: Production in Mice Fed with Cuprizone
- 3 January 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 163 (3862), 81-82
- https://doi.org/10.1126/science.163.3862.81
Abstract
Giant mitochondria in hepatocytes that have the average size of nuclei can be consistently produced in the liver of weanling mice by feeding them cuprizone (bis-cyclohexanone oxaldihydrazone). The simplicity of the procedure and the consistency of the results make the feeding of cuprizone a new and useful experimental tool for the study of mitochondrial metabolism.Keywords
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