Methotrexate in Childhood Psoriasis
- 1 September 1994
- journal article
- Published by Wiley in Pediatric Dermatology
- Vol. 11 (3), 271-273
- https://doi.org/10.1111/j.1525-1470.1994.tb00602.x
Abstract
We treated childhood psoriasis with methotrexate (MTX) in seven children (4 boys, 3 girls) over 7.5 years. Their ages and duration of disease varied from 3.5 to 16 years (mean 12.14 yrs) and 4.8 months to 5 years (mean 2.2 yrs), respectively. Psoriatic erythroderma was seen in three patients, generalized pustular psoriasis in two, recalcitrant psoriasis and psoriatic arthropathy in one each. Pre-MTX liver biopsy performed in 4 children showed grade I changes. Methotrexate was given in a single weekly oral dose of 3.75 to 25 mg (mean 16.6 mg). The duration of treatment necessary to control the disease varied from 6 to 10 weeks (mean 7.9 wks). Total duration of MTX therapy was 31.2 to 46.4 weeks (mean 38.8 wks). Posttherapy disease-free interval ranged between 14.4 and 16.8 weeks (mean 15.5 wks). Follow-up after withdrawal of MTX was 16 to 28 weeks (mean 22.3 wks). Total cumulative MTX dose ranged from 390 to 960 mg (mean 683.6 mg). Side effects were nausea and vomiting in three patients.Keywords
This publication has 18 references indexed in Scilit:
- Pustular psoriasis in childhoodClinical and Experimental Dermatology, 1993
- The role of liver biopsies in psoriatic patients receiving long-term methotrexate treatment. Improvement in liver abnormalities after cessation of treatmentArchives of Dermatology, 1989
- Methotrexate in psoriasis: Revised guidelinesJournal of the American Academy of Dermatology, 1988
- The RetinoidsDrugs, 1987
- Etretinate therapy for generalized pustular psoriasis in childrenArchives of Dermatology, 1987
- Do spray coolant anesthetics contaminate an aseptic field?Arthritis & Rheumatism, 1986
- Low incidence of hepatotoxicity associated with long-term, low-dose oral methotrexate in treatment of refractory psoriasis, psoriatic arthritis, and rheumatoid arthritisDigestive Diseases and Sciences, 1985
- Commentary: three decades of folic acid antagonists in dermatologyArchives of Dermatology, 1983
- Juvenile generalized pustular psoriasis. A report of five cases and a review of the literatureArchives of Dermatology, 1972
- Studies on the folic acid vitamins.IV. The persistence of amethopterin in mammalian tissuesCancer, 1960