METABOLIC EFFECTS OF SOME HALOGENATED ACRYLIC ACID ANALOGUES OF THYROXINE1
- 1 January 1951
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 48 (1), 70-74
- https://doi.org/10.1210/endo-48-1-70
Abstract
The essential features of the thyroxine molecule are [image] In this study, thyroxine-like activity (increased oxygen consumption in rats) increased when R was changed from an amino group to an acrylic acid to a propionic acid. With any given R, iodine in the 3,5 positions imparted more activity than bromine and addition of 2 more atoms of the particular halogen in questinn at 3[image],5[image] yielded still further increases.Keywords
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