Effect of 1-(2,4-dichlorobenzyl)-indazole-3-carboxylic acid on sperm tails in rhesus monkeys
- 1 March 1978
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 52 (2), 275-278
- https://doi.org/10.1530/jrf.0.0520275
Abstract
Large numbers of spermatozoa with bent or coiled tails were found in the ejaculates of rhesus monkeys treated with 1-(2,4-dichlorobenzyl-indazole-3-carboxylic acid (DICA) (50 or 500 mg/kg for various periods). The defect appeared only in spermatozoa in the cauda epididymidis and consisted of axoneme disarrangement and loss of fiber doublets. The coil was completely enclosed in a membrane. [DICA is a potential contraceptive agent.].This publication has 5 references indexed in Scilit:
- 1-Halobenzyl-1H-indazole-3-carboxylic acids. A new class of antispermatogenic agentsJournal of Medicinal Chemistry, 1976
- Evidence by Scanning Electron Microscopy for an Association between Spermatozoa and T-Mycoplasmas in Men of Infertile MarriageFertility and Sterility, 1975
- A New Sterilizing and Hereditary Defect (the ‘Dag Defect’) located in the Bull Sperm TailNature, 1966
- Changes in the Epididymis Associated with Morphological Changes in the SpermatozoaJournal of Dairy Science, 1965
- MICRODISSECTION STUDIES ON HUMAN SPERMATOZOAThe Biological Bulletin, 1929