Activation of STAT proteins and growth control
- 17 January 2001
- Vol. 23 (2), 161-169
- https://doi.org/10.1002/1521-1878(200102)23:2<161::aid-bies1023>3.0.co;2-0
Abstract
This review will discuss how STAT (Signal Transducers and Activators of Transcription) proteins, a group of transcription factors that transmit signals from the extracellular surface of cells to the nucleus, are involved in growth control. I will discuss the anatomy of a STAT protein, how it works as a transcription factor, the molecules that regulate its "activity", the phenotypes of mice that lack individual STAT proteins and their involvement in growth, differentiation, apoptosis, and transformation. Finally, a number of examples will be presented of how dysregulated STAT signaling may be involved in the pathogenesis of cancer.Keywords
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