EPIDERMAL GROWTH FACTOR STIMULATES PRODUCTION OF PROGESTERONE IN CULTURED HUMAN CHORIOCARCINOMA CELLS
- 1 December 1980
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 107 (6), 2121-2123
- https://doi.org/10.1210/endo-107-6-2121
Abstract
Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Stimulation occurs in a time and dose-dependent manner. In addition, EGF increases [14C]-acetate incorporation into [14C]-cholesterol in JEG-3 cells, and this may constitute its mechanism of action in enhancing progesterone synthesis.Keywords
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