Effect of Neostigmine on Integrity of Ileorectal Anastomoses
- 7 September 1968
- Vol. 3 (5618), 587-588
- https://doi.org/10.1136/bmj.3.5618.587
Abstract
Patients undergoing total colectomy and ileorectal anastomosis for chronic ulcerative colitis were divided into two groups depending on whether neostigmine was administered during the anaesthetic to reverse the muscle relaxant. Those receiving neostigmine showed a postoperative anastomotic leakage rate of 36%. In the group not receiving neostigmine the leak rate was 4%, an apparently highly significant difference. Neostigmine may produce this effect by causing contractions of the gut musculature or by vasoconstriction of the blood vessels to the suture line, resulting in local ischaemia.Keywords
This publication has 8 references indexed in Scilit:
- The effect of neostigmine methyl sulphate on the human colon in health and in diverticulosis.1967
- Vaccination against leprosy.1966
- The intraluminal pressure patterns in diverticulosis of the colon : Part III The effect of prostigmineGut, 1964
- THE AETIOLOGY OF DIVERTICULOSIS OF THE COLON WITH SPECIAL REFERENCE TO THE ACTION OF CERTAIN DRUGS ON THE BEHAVIOUR OF THE COLON.1964
- Endoradiosonde study of propulsion and pressure activity induced by test meals, Prostigmine, and diphenoxylate in the small intestineGut, 1964
- The effect of atropine and neostigmine on the pulse rates of anaesthetised patientsAnaesthesia, 1962
- Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. II. The effect of prostigmin.1961
- ANTIDOTES TO ‘TRUE' CURARIZING AGENTS including a report on Ro 2–3198 (Tensilon)British Journal of Anaesthesia, 1952