Racial differences in serum total bilirubin levels in health and in disease (pernicious anemia)
- 21 June 1985
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 253 (23), 3416-3418
- https://doi.org/10.1001/jama.253.23.3416
Abstract
Common usage prescribes a single normal range for serum bilirubin levels. However, we have not only confirmed that men have higher levels than women but have discovered significant racial differences as well. Among 1,538 healthy Americans, blacks had lower mean bilirubin levels than whites of European origin, Latin Americans, and Asians. These racial differences, which were more pronounced among women than men, were maintained in pernicious anemia. Even though bilirubin levels rose in our 174 patients with this disease, they continued to be lower among blacks than among whites and Latin Americans. Moreover, the actual bilirubin level changes caused by pernicious anemia were themselves smaller among blacks. The racial differences, thus, persisted in pernicious anemia despite similar degrees of anemia, whereas the sex differences disappeared. We suggest that the lower serum bilirubin levels in blacks in health and disease do not stem primarily from lower bilirubin production than in whites. (JAMA1985;253:3416-3418)This publication has 9 references indexed in Scilit:
- Heterogeneity of Serum Creatine Kinase Activity among Racial and Gender Groups of the PopulationAmerican Journal of Clinical Pathology, 1983
- Clinical and subclinical thyroid disorders associated with pernicious anemia. Observations on abnormal thyroid-stimulating hormone levels and on a possible association of blood group O with hyperthyroidismArchives of Internal Medicine, 1982
- Profiles of Black and Latin-American Patients Having Pernicious Anemia: HLA Antigens Lymphocytotoxic Antibody, Anti-Parietal Cell Antibody, Serum Gastrin Levels, and ABO Blood GroupsAmerican Journal of Clinical Pathology, 1981
- Racial Patterns in Pernicious AnemiaNew England Journal of Medicine, 1978
- DOES GILBERT'S DISEASE EXIST?The Lancet, 1977
- The Effects of Race, Weight Loss and the Time of Clamping of the Umbilical Cord on Neonatal BilirubinemiaNeonatology, 1963
- Erythrokinetics in Pernicious AnemiaBlood, 1956
- LIVER FUNCTION IN UNTREATED ADDISONIAN PERNICIOUS ANEMIA1952
- THE FORMATION OF BILE PIGMENT IN PERNICIOUS ANEMIAJournal of Biological Chemistry, 1950