Mutagenicity studies with Praziquantel, a new anthelmintic drug, in mammalian systems
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 39 (3), 187-197
- https://doi.org/10.1007/bf00368227
Abstract
Praziquantel, a new anthelmintic drug with antischistosomal and anticestodal properties, was tested in comparison with a placebo control and a ‘positive control’ with cyclophosphamide in mammalian test systems in vivo for potential mutagenic effects. The test systems used and the tested doses of Praziquantel were: (1) Dominant lethal test on male NMRI mice, 12 mating periods of 4 days each, 1×1200 mg/kg BW by mouth; (2) Dominant lethal test on female NMRI mice, treatment during pre-estrus, 1×1200 mg/kg BW by mouth; (3) Micronucleus test on male and female NMRI mice, two doses with a 24-h interval and preparation of the femoral marrow 6 h after the second dose, 2 ×300 mg/kg and 2×600 mg/kg BW by mouth; (4) Spermatogonial test on the Chinese hamster, two doses with a 24-h interval and preparation of the spermatogonia 48 h after the second dose, 2×600 mg/kg BW by mouth. The 1200 mg/kg BW dose corresponded to approximately 1/2 of the LD50 after oral application in the mouse and about 40 times the therapeutic dose (1×30 mg/kg BW). The cyclophosphamide doses in the test systems were 1×200 mg/kg or 2 ×200 mg/kg BW by mouth. No indication was found of any mutagenic potency of Praziquantel. This agrees with the results of point-mutation tests done by other authors.Keywords
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