Synthesis And Biological Activity Op Hydpdxymetflyl Analogs op 5-Benzylacyclouridine and 5-Benzyloxybenzylacycloaridine
- 3 January 1984
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 3 (3), 303-311
- https://doi.org/10.1080/07328318408081267
Abstract
Hydroxymethyl [HM] analogs of 5-benzylacyclouridine (BAU) and 5-benzyloxybenzylacyclouridine (BBAU) were synthesized by the condensation of appropriately blocked 2-(chloromethyl)glycerols with substituted 2,4-dimethoxypyrimidines. The HM derivatives were potent inhibitors of the enzyme uridine phosphorylase and significantly potentiated the growth-inhibiting action of FdUrd [5-fluoro-2''-deoxyuridine] in cell culture [suggesting their potential use as antiviral agents].This publication has 10 references indexed in Scilit:
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