Obesity and Cancer Susceptibility in Mice
Open Access
- 1 September 1960
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 8 (5), 760-766
- https://doi.org/10.1093/ajcn/8.5.760
Abstract
In summary, we have shown that mice can be made obese by injection of gold thioglucose. Animals so treated develop lesions in the hypothalamus and subsequently become obese. Animals made obese by this technic show two interesting phenomena: such mice have an augmentation of tumor production and truly obese animals do not become pregnant. Hormonal imbalance occurs when hypothalamic obesity is produced. A condition results which apparently allows sufficient estrogen production to induce an increase in tumor production and at the same time keeps these obese animals from going through a normal estrus cycle.This publication has 6 references indexed in Scilit:
- Organ Weights and Obesity in MiceJournal of Nutrition, 1954
- Studies on the Occurrence of Spontaneous Hepatomas in Mice of Strains C3H and CBA2JNCI Journal of the National Cancer Institute, 1950
- OBESITY AND FOOD REQUIREMENTS IN ALBINO MICE FOLLOWING ADMINISTRATION OF GOLDTHIOGLUCOSEAmerican Journal of Physiology-Legacy Content, 1950
- Obesity in Albino Mice Due to Single Injections of GoldthioglucoseExperimental Biology and Medicine, 1949
- EXTRINSIC FACTORS THAT INFLUENCE CARCINOGENESISPhysiological Reviews, 1944
- Some Possible Effects of Nursing on the Mammary Gland Tumor Incidence in MiceScience, 1936