Habituation of Rostral Anterior Cingulate Cortex to Repeated Emotionally Salient Pictures
- 26 February 2003
- journal article
- research article
- Published by Springer Nature in Neuropsychopharmacology
- Vol. 28 (7), 1344-1350
- https://doi.org/10.1038/sj.npp.1300186
Abstract
Habituation of the neural response to repeated stimuli has been well demonstrated for subcortical limbic regions responding to emotionally salient stimuli. Although the rostral or affective division of the anterior cingulate cortex (rACC) is also engaged during emotional processing, little is known about the temporal dynamics of this region in sustained evaluation of emotional salience. Using a test/retest design, the present study assessed habituation in the human brain with functional magnetic resonance imaging. Eight healthy subjects were exposed to two repeated runs of aversive, neutral, and blank images. Activation of the rACC to negatively valenced pictures occurred only in the first session, and this activation was significantly greater in the first relative to the second session. Additionally, medial prefrontal cortex, hippocampal, and amygdalar activations were noted during the first, but not second, presentation of aversive pictures. These findings highlight the phasic activity of the rACC in emotional processing consistent with habituation.Keywords
This publication has 38 references indexed in Scilit:
- Volitional Control of Autonomic Arousal: A Functional Magnetic Resonance StudyNeuroImage, 2002
- Functional Neuroanatomy of Emotion: A Meta-Analysis of Emotion Activation Studies in PET and fMRINeuroImage, 2002
- Cognitive and emotional influences in anterior cingulate cortexTrends in Cognitive Sciences, 2000
- Emotion Circuits in the BrainAnnual Review of Neuroscience, 2000
- Contribution of Ventrolateral Prefrontal Cortex to the Acquisition and Extinction of Conditioned Fear in RatsNeurobiology of Learning and Memory, 1999
- Suppression of Regional Cerebral Blood during Emotional versus Higher Cognitive Implications for Interactions between Emotion and CognitionCognition and Emotion, 1998
- Response and Habituation of the Human Amygdala during Visual Processing of Facial ExpressionNeuron, 1996
- Analysis of fMRI Time-Series RevisitedNeuroImage, 1995
- Contributions of anterior cingulate cortex to behaviourBrain, 1995
- Habituation: A model phenomenon for the study of neuronal substrates of behavior.Psychological Review, 1966