Transforming Potential of the Anticancer Drug Adriamycin
- 28 March 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 187 (4182), 1200-1201
- https://doi.org/10.1126/science.1167703
Abstract
A Fischer rat embryo cell system in vitro, which had been shown to be highly accurate in identifying chemical carcinogens and to have application in the study of chemicals having anticancer properties, was used to study the anticancer drug adriamycin. At a nontoxic dose adriamycin not only did not protect the cells from transformation by the carcinogen 3-methylcholanthrene, but was found in two separate experiments to act on its own as a transforming agent.Keywords
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