Efficacy of Different β-Lactams against an Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Strain in the Rat Intra-Abdominal Abscess Model

Abstract

Although standard-inoculum MICs were within the susceptible range for all compounds, cefoperazone, cefotaxime, and cefpirome were significantly less effective than imipenem or the combination of cefoperazone and sulbactam in the treatment of rat intra-abdominal abscesses due to an extended-spectrum β-lactamase-producing strain of Klebsiella pneumoniae .