The intracellular calcium antagonist TMB-8 [8-(NN-diethylamino)octyl-3,4,5-trimethoxybenzoate] inhibits mitochondrial ATP production in rat thymocytes
- 15 December 1984
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 224 (3), 1027-1030
- https://doi.org/10.1042/bj2241027
Abstract
TMB-8 inhibited respiration of rat thymocytes and rat liver mitochondria, probably by inhibition of NADH dehydrogenase. TMB-8 markedly decreased both the cellular ATP concentration and the mitochondrial membrane potential in situ in thymocytes. These effects occurred at, or well below, the concentrations used in other systems to investigate the role of intracellular Ca pools in signaling events. Caution should be exercised in the interpretation of the effects of TMB-8.This publication has 27 references indexed in Scilit:
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