Passive Cutaneous Anaphylaxis with Antibody Fragments
- 12 April 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 140 (3563), 193-195
- https://doi.org/10.1126/science.140.3563.193
Abstract
Pepsin-digested rabbit antibody (5S) provoked reverse passive cutaneous anaphylaxis in the guinea pig, but was somewhat less effective, mole for mole, than the native antibody. Fixation of guinea pig complement by the pepsin-digested antibody could not be demonstrated either in vitro or in vivo. Splitting of the 5S fragment into two monovalent fragments (3.5S) markedly reduced the capacity to provoke reverse passive cutaneous anaphylaxis.Keywords
This publication has 14 references indexed in Scilit:
- Biological Activity of Soluble Antigen-Antibody ComplexesThe Journal of Immunology, 1962
- Complement Fixation by Antibody FragmentsScience, 1961
- Interaction of Fragment III of Rabbit Gamma Globulin and Guinea Pig Complement.Experimental Biology and Medicine, 1961
- Separation of Univalent Fragments of Rabbit Antibody by Reduction of a Single, Labile Disulphide BondNature, 1961
- Functions of the Complement SystemAdvances in Immunology, 1961
- Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bondsArchives of Biochemistry and Biophysics, 1960
- QUANTITATIVE STUDIES OF COMPLEMENT FIXATIONMicrobiology and Molecular Biology Reviews, 1958
- Passive Sensitization of the Skin of the Guinea Pig with Human AntibodyInternational Archives of Allergy and Immunology, 1954
- The effect of peptic digestion on the properties of diphtheria antitoxinProceedings of the Royal Society of London. B. Biological Sciences, 1951
- A Quantitative Study of Passive Anaphylaxis in the Guinea Pig. IV.The Journal of Immunology, 1949