Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study
- 10 December 2003
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 47 (1), 31-39
- https://doi.org/10.1007/s00125-003-1263-9
Abstract
Both insulin resistance and beta-cell dysfunction play a role in the transition from normal glucose tolerance (NGT) to Type 2 diabetes (T2DM) through impaired glucose tolerance (IGT). The aim of the study was to define the level of glycaemia at which beta-cell dysfunction becomes evident in the context of existing insulin resistance.Keywords
This publication has 44 references indexed in Scilit:
- The Importance of β-Cell Failure in the Development and Progression of Type 2 DiabetesJournal of Clinical Endocrinology & Metabolism, 2001
- Glucagon-Like PeptidesDiabetes, 1998
- Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin ResistanceNew England Journal of Medicine, 1996
- Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up studyThe Lancet, 1992
- Glucose ToxicityDiabetes Care, 1990
- Impaired Glucose Tolerance as a Disorder of Insulin ActionNew England Journal of Medicine, 1988
- Low Insulin Response: A Marker Of PrediabetesPublished by Springer Nature ,1988
- Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.Journal of Clinical Investigation, 1987
- Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*Journal of Clinical Investigation, 1967
- IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MANJournal of Clinical Investigation, 1960