Distribution of spontaneous chromosome breaks in human chromosomes
- 1 March 1976
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 32 (2), 143-148
- https://doi.org/10.1007/bf00291497
Abstract
Localization of chromosome breaks in human chromosomes was analyzed in 264 peripheral lymphocyte cultures. Three hundred and sixty-nine chromosome breaks could be exactly localized to a chromosome band or region of the Paris Conference nomenclature. The distribution of breaks in the chromosome regions was found to be nonrandom. Chromosome 3 alone had 23% of the breaks and region 3p2 had 13% of the total breaks. Some other chromosome regions, such as 5p1, 9q1, 14q2, and 16q2 also displayed clustering of breaks. Sex chromosomes had less breaks than expected. Spontaneous chromosome breaks were almost exclusively located in the lightly stained G bands.This publication has 17 references indexed in Scilit:
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