Application of N,N‐dimethylformamide dineopentyl acetal for efficient anchoring of Nα‐9‐fluorenylmethyloxycarbonylamino‐acids as p‐alkoxybenzyl esters in solid‐phase peptide synthesis
- 1 April 1984
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 23 (4), 342-349
- https://doi.org/10.1111/j.1399-3011.1984.tb02729.x
Abstract
The attachment of Fmoc-amino acids [Fmoc = 9-fluorenylmethyloxy carbonyl] onto p-alkoxybenzyl alcohol resins via DCC-DMAP [dicyclohexyl carbodiimide-4-dimethylaminopyridine] coupling suffers from 2 different problems: formation of dimers and racemization. The use of N,N-dimethylformamide dineopentyl acetal for the preparation of Fmoc-aminoacyloxybenzyl handles is the basis of a safe and efficient anchoring method that avoids both problems.Keywords
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