Characterization of the Fibrinolytic State by Measuring Stable Cross-Linked Fibrin Degradation Products in Disseminated Intravascular Coagulation Associated with Acute Promyelocytic Leukemia
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 81 (1), 15-18
- https://doi.org/10.1159/000205392
Abstract
Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(d)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than samples of DIC with non-APL. The difference between FDP(D) and XDP levels increased only when .alpha.2-plasmin inhibitor (.alpha.2-PI) fell below 60% of the normal level in APL patients. These findings suggest that fibrinogenolysis occurs in APL patients with the .alpha.2-PI level has decreased significantly.This publication has 5 references indexed in Scilit:
- Elevated serum D dimer: A degradation product of cross-linked fibrin (XDP) after intravenous streptokinase during acute myocardial infarctionJournal of the American College of Cardiology, 1986
- Serum crosslinked fibrin (XDP) and fibrinogen/fibrin degradation products (FDP) in disorders associated with activation of the coagulation or fibrinolytic systemsBritish Journal of Haematology, 1985
- Selective determination of α2-plasmin inhibitor activity in plasma using chromogenic substrateThrombosis Research, 1984
- Giant fibrin fragments derived from crosslinked fibrin: Structure and clinical implicationThrombosis Research, 1980
- Role of α2-plasmin inhibitor in the appearance of fibrinolytic activity during urokinase administration, and an evaluation of the optimal urokinase dosageThrombosis Research, 1979