Immunological mechanisms in metastatic spread and the antimetastatic effects of C. parvum
Open Access
- 30 April 1977
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 35 (5), 519-527
- https://doi.org/10.1038/bjc.1977.85
Abstract
The effects of the host's immune response on metastatic spread was investigated by observing the numbers of pulmonary metastases that developed from an s.c. implant of the Lewis lung carcinoma in C57BL mice in which different cell populations had been suppressed. Macrophage function was impaired by treatment with silica (Si), cortisone acetate (CA), or trypan blue (TB). T-cell function was depressed by adult thymectomy and sublethal irradiation, or by treatment with antilymphocyte serum (ALS). Metastasis was significantly increased and phagocytic activity decreased by Si and CA, but were unaffected by TB. Thymectomy and irradiation had no effect on metastases, whereas ALS when given before, but not after tumour growth, reduced their number. The antimetastatic action of the immunopotentiating agent C. parvum was investigated in these immunologically impaired mice. It was unaffected by Si, CA or TB. However, the inhibiting effect of these agents on phagocytic activity was overcome by treatment with C. parvum. Its antimetastatic action was unaffected in mice which had been thymectomized and irradiated, but could be abrogated by ALS. However, ALS was only able to prevent this activity if given before tumour growth, it was ineffective if given after tumour growth. This study showed that metastatic spread was inversely related to phagocytic activity. The antimetastatic effect of C. parvum appears to be mediated through macrophages in concert with a subpopulation of T lymphocytes, which were considered to be necessary in the sensitization arm of the response as opposed to the effector arm of this response.Keywords
This publication has 29 references indexed in Scilit:
- Effects of Intravenous Silica on Immune and Non-Immune Functions of the Murine HostThe Journal of Immunology, 1975
- ACTIVATED MACROPHAGES AS CYTOTOXIC EFFECTOR CELLSTransplantation, 1975
- ORIGIN AND DIVISION OF LIVER MACROPHAGES DURING STIMULATION OF THE MONONUCLEAR PHAGOCYTE SYSTEMCell Proliferation, 1974
- Surgical procedures in small laboratory animalsJournal of Immunological Methods, 1974
- Increased incidence of lung metastases following treatment of rats bearing hepatomas with irradiated tumour cells and the benefical effect of Corynebacterium parvum in this system.1973
- Corticosteroids and Lymphoid CellsNew England Journal of Medicine, 1972
- THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE KINETICS OF MONONUCLEAR PHAGOCYTESThe Journal of Experimental Medicine, 1970
- Lysosomal Enzyme Inhibition by Trypan Blue: A Theory of TeratogenesisScience, 1967
- Inhibition of Tumour Growth by Administration of Killed Corynebacterium parvumNature, 1966
- AN EXAMINATION OF THE CYTOTOXIC EFFECTS OF SILICA ON MACROPHAGESThe Journal of Experimental Medicine, 1966