Polypeptides. Part 17. Aminoxy-analogues of aspartame and gastrin C-terminal tetrapeptide amide
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 2138-2143
- https://doi.org/10.1039/p19790002138
Abstract
L- and D-2-Aminoxy-3-phenylpropionic acid have been prepared from D- and L-phenylalanine by a route which is generally applicable to other optically active amino-acids. Appropriate methodology enabled incorporation of the L-isomer in place of L-phenylalanine in Asp-Phe-OMe (to provide an aminoxy-analogue which was not sweet) and Trp-Met-Asp-Phe-NH2, (to provide an aminoxy-analogue which did not stimulate gastric acid secretion).This publication has 4 references indexed in Scilit:
- Polypeptides. Part 16. Synthesis and biological activity of α-aza-analogues of luliberin with high antagonist activityJournal of the Chemical Society, Perkin Transactions 1, 1979
- α-aminooxy-β-phenylpropionic acid — a potent inhibitor of L-phenylalanine ammonia-lyase in vitro and in vivoPlant Science Letters, 1977
- Structure–Function Relationships in the Active C-Terminal Tetrapeptide Sequence of GastrinNature, 1965
- 85. O, N-substituierte Hydroxylamine V. Mitt.) Über Synthese und Eigenschaften der α-Aminoxy-Carbonsäuren, Analoga natürlicher α-AminocarbonsäurenHelvetica Chimica Acta, 1963