Prostaglandin Synthesis and Inactivation in Kidneys and Lungs of Rats with Experimental Diabetes
- 1 July 1980
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 59 (1), 63-66
- https://doi.org/10.1042/cs0590063
Abstract
Microsomal prostaglandin [PG] synthesis and tissue PG concentrations in the kidneys of rats made diabetic by pretreatment with alloxan or streptozotocin were significantly decreased but were unchanged in lungs. PG inactivation was increased in kidneys of alloxan-diabetic rats but not changed in streptozotocin-diabetic kidneys or in the lungs of either group. These changes in PG metabolism may cause a renal PG deficit and could contribute to certain pathological sequelae observed in diabetes mellitus.This publication has 2 references indexed in Scilit:
- Increased Synthesis of Prostaglandin-E-like Material by Platelets from Patients with Diabetes MellitusNew England Journal of Medicine, 1977
- Increased Platelet Aggregation in Early Diabetus MellitusAnnals of Internal Medicine, 1975