In an underdeveloped community there are many logistic difficulties in the control and management of diabetes mellitus. Because it often was impossible to carry out insulin therapy at home, one of us (R.R.) made early use of oral hypoglycemic drugs in the diabetic clinic at the University of the West Indies in Kingston. Since 1961 sulfonylureas have been used in pregnant diabetic patients. The present report describes the results of chlorpropamide treatment in 34 pregnant diabetic women.