Preliminary studies of absorption and excretion of benoxaprofen in man.
- 1 October 1977
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 4 (5), 585-590
- https://doi.org/10.1111/j.1365-2125.1977.tb00790.x
Abstract
1 Benoxaprofen is a new acidic anti‐inflammatory compound which was well absorbed after oral administration to man. 2 Single doses of 100, 200 and 400 mg produced mean peak concentrations in the plasma of 13.0, 33.5 and 45.3 microgram respectively, and the plasma half‐life of the compound was between 30 and 35 hours. 3 Multiple dosing with 25 and 50 mg every 24 h achieved an equilibrium conentration in the plasma after 6‐8 days, while dosing with 100 mg every 12 h enabled equilibrium to be reached in 3‐6 days. Plasma concentrations between 35 and 45 microgram/ml were achieved by giving 100 mg doses every 12 hours. 4 Absorption of benoxaprofen was delayed when the drug was given with food, but the total amount absorbed remained the same. 5 The effect of milling the material to small particle size (19 micron) was to increase the rate of absorption compared to that of unmilled material (58 micron). 6 Benoxaprofen was well tolerated by healthy male subject in the doses given.Keywords
This publication has 8 references indexed in Scilit:
- Pharmacokinetic studies with benoxaprofen in man: prediction of steady- state levels from single-dose data.British Journal of Clinical Pharmacology, 1977
- The pharmacology of benoxaprofen (2-[4-chlorophenyl]-α-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with anti-inflammatory activity apparently unrelated to inhibition of prostaglandin synthesisJournal of Pharmacy and Pharmacology, 1977
- Relation between plasma concentration and therapeutic efficacy of a new anti-inflammatory compound, benoxaprofen (LRCL 3794) in rats with adjuvant-induced arthritisJournal of Pharmacy and Pharmacology, 1977
- Administration of antirheumatic drugs.Annals Of The Rheumatic Diseases, 1976
- 2-Aryl-5-benzoxazolealkanoic acid derivatives with notable antiinflammatory activityJournal of Medicinal Chemistry, 1975
- GASTRIC EMPTYING AND DRUG ABSORPTIONBritish Journal of Clinical Pharmacology, 1974
- Effect of a New Anti-Inflammatory Drug, Fenoprofen, on Platelet Aggregation and Thrombus FormationExperimental Biology and Medicine, 1972
- A comparison of an effect of different anti-inflammatory drugs on human plateletsJournal of Clinical Pathology, 1970