Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3' end of the C3b/C4b receptor gene.
Open Access
- 1 February 1989
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 169 (2), 597-602
- https://doi.org/10.1084/jem.169.2.597
Abstract
The structural gene for membrane cofactor protein (MCP), a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system, has been mapped to the same locus as the structural genes for CR1, CR2, DAF, and C4bp. The order of the genes within an approximately 800-kb DNA fragment on the long arm of chromosome 1 is MCP-CR1-CR2-DAF-C4bp. Further, the MCP gene maps to within 100 kb of 3' end of the CR1 gene.Keywords
This publication has 19 references indexed in Scilit:
- Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.Proceedings of the National Academy of Sciences, 1987
- A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.The Journal of Immunology, 1987
- Molecular analysis of the Duchenne muscular dystrophy region using pulsed field gel electrophoresisCell, 1987
- Identification of a third component of complement-binding glycoprotein of human platelets.Journal of Clinical Investigation, 1986
- Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b.The Journal of Experimental Medicine, 1986
- Human genes for three complement components that regulate the activation of C3 are tightly linked.The Journal of Experimental Medicine, 1985
- Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines.Proceedings of the National Academy of Sciences, 1985
- Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresisNucleic Acids Research, 1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- The bidirectional transfer of DNA and RNA to nitrocellulose or diazobenzyloxymethyl-paperAnalytical Biochemistry, 1980