The structures of toxic metabolites of Aspergillus candidus. I. The compounds A and E, cytotoxic p-terphenyls.

Abstract

The metabolites, compounds A-E, were isolated from a toxic strain of A. candidus and the structures of the characteristic cytotoxic compounds A (terphenyllin) and E(deoxyterphenyllin) were elucidated to p-terphenyl derivatives by spectral data, oxidation reactions and synthesis of compound A trimethyl ether. The cytotoxicity of the compounds and the derivatives were also discussed.