Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors
Open Access
- 1 June 2008
- journal article
- Published by Oxford University Press (OUP) in Neuro-Oncology
- Vol. 10 (3), 320-329
- https://doi.org/10.1215/15228517-2008-012
Abstract
The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral distribution of a recombiKeywords
This publication has 57 references indexed in Scilit:
- Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusionsNeuro-Oncology, 2007
- Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13—PE38QQR for recurrent malignant gliomaJournal of Neurosurgery, 2005
- Distribution kinetics of targeted cytotoxin in glioma by bolus or convection-enhanced delivery in a murine modelJournal of Neurosurgery, 2004
- The blood-brain and blood-tumor barriers: A review of strategies for increasing drug deliveryNeuro-Oncology, 2000
- Comparison of 14C-sucrose delivery to the brain by intravenous, intraventricular, and convection-enhanced intracerebral infusionJournal of Neurosurgery, 1999
- Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with singlephoton emission computerized tomography imagingJournal of Neurosurgery, 1997
- Expression of the epidermal growth factor receptor gene in human brain metastasesAPMIS, 1992
- Recombinant Toxins for Cancer TreatmentScience, 1991
- Epidermal growth factor receptor expression in human gliomasCancer Immunology, Immunotherapy, 1991
- Effects of treatment on long‐term survivors with malignant astrocytomasAnnals of Neurology, 1990